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apalutamide will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicines which are CYP3A4 substrates may lead to decreased publicity to these prescription drugs.4.8 Undesirable outcomes Commo